What is Ativan (Lorezepam) and how is it used?

Ativan (Lorezepam) is a prescription medicine used to treat the symptoms of anxiety disorders. Ativan may be used alone or with other medications.

Ativan (Lorezepam) belongs to a class of drugs called Antianxiety Agents, Anxiolytics, Benzodiazepines, Anticonvulsants, Benzodiazepine.

What are the possible side effects of Ativan (Lorezepam)?

Ativan (Lorezepam) may cause serious side effects including:

  • severe drowsiness,
  • thoughts of suicide or hurting yourself,
  • unusual changes in mood or behavior,
  • confusion,
  • aggression,
  • hallucinations,
  • worsened sleep problems,
  • sudden restless feeling or excitement,
  • muscle weakness,
  • drooping eyelids,
  • trouble swallowing,
  • vision changes,
  • upper stomach pain,
  • dark urine, and
  • yellowing of the skin or eyes (jaundice)

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of Ativan include:

  • dizziness,
  • drowsiness,
  • weakness,
  • slurred speech,
  • lack of balance or coordination,
  • memory problems, and
  • feeling unsteady

Tell the doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Ativan. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

DESCRIPTION

Ativan (lorazepam), an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3- dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one:

 

 

Ativan®(lorazepam) Structural Formula Illustration

C15H10Cl2N2O2     MW: 321.16

It is a nearly white powder almost insoluble in water. Each Ativan (lorazepam) tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of lorazepam. The inactive ingredients present are lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.

Indications & Dosage

INDICATIONS

Ativan (lorazepam) is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.

The effectiveness of Ativan (lorazepam) in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.DOSAGE AND ADMINISTRATION

Ativan (lorazepam) is administered orally. For optimal results, dose, frequency of administration, and duration of therapy should be individualized according to patient response. To facilitate this, 0.5 mg, 1 mg, and 2 mg tablets are available.

The usual range is 2 to 6 mg/day given in divided doses, the largest dose being taken before bedtime, but the daily dosage may vary from 1 to 10 mg/day.

For anxiety, most patients require an initial dose of 2 to 3 mg/day given two times a day or three times a day.

For insomnia due to anxiety or transient situational stress, a single daily dose of 2 to 4 mg may be given, usually at bedtime.

For elderly or debilitated patients, an initial dosage of 1 to 2 mg/day in divided doses is recommended, to be adjusted as needed and tolerated.

The dosage of Ativan (lorazepam) should be increased gradually when needed to help avoid adverse effects. When higher dosage is indicated, the evening dose should be increased before the daytime doses.

Discontinuation Or Dosage Reduction Of Ativan

To reduce the risk of withdrawal reactions, use a gradual taper to discontinue Ativan or reduce the dosage. If a patient develops withdrawal reactions, consider pausing the taper or increasing the dosage to the previous tapered dosage level. Subsequently decrease the dosage more slowly (see WARNINGSDependence And Withdrawal Reactions and Drug Abuse And DependenceDependence).

HOW SUPPLIED

Ativan® (lorazepam) Tablets are available in the following dosage strengths:

0.5 mg, white, five-sided (shield shape) tablet with a raised “A” on one side and “BPI” and “63” impressed on reverse side.

NDC 0187-0063-01 -Bottles of 100 tablets.

1 mg, white, five-sided (shield shape) tablet with a raised “A” on one side and “BPI” and “64” impressed on scored reverse side.

NDC 0187-0064-01 -Bottles of 100 tablets.
NDC 0187-0064-10 -Bottles of 1,000 tablets.

2 mg, white, five-sided (regular pentagon) tablet with a raised “A” and impressed “2” on one side and “BPI” and “65” impressed on scored reverse side.

NDC 0187-0065-01 -Bottles of 100 tablets.

Keep bottles tightly closed.

Keep out of reach of children.

Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].

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