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The higher strength of Oxycodone (more than 40 milligrams per tablet) should be used only if you have been regularly taking moderate to large amounts of narcotic pain medication. These strengths may cause overdose (even death) if taken by a person who has not been regularly taking narcotic medication.

Do not use the extended-release form of oxycodone to relieve pain that is mild or that will go away in a few days. This medication is not for occasional (“as needed”) use .

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Oxycodone is a pure agonist opioid whose principal therapeutic action is analgesia. Other members of the class known as opioid agonists include substances such as morphine, hydromorphone, fentanyl, codeine, and hydrocodone. Pharmacological effects of opioid agonists include anxiolysis, euphoria, feelings of relaxation, respiratory depression, constipation, miosis, and cough suppression, as well as analgesia.

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Like all pure opioid agonist analgesics, with increasing doses there is increasing analgesia, unlike with mixed agonist/antagonists or non-opioid analgesics, where there is a limit to the analgesic effect with increasing doses. With pure opioid agonist analgesics, there is no defined maximum dose; the ceiling to analgesic effectiveness is imposed only by side effects, the more serious of which may include somnolence and respiratory depression.Oxycoedone 80mg

The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and play a role in the analgesic effects of this drug.

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There are serious health risks associated with using oxycodone, including severe or life-threatening breathing problems, particularly in the first 72 hours of treatment and any time the dose is increased.

Tell your doctor if you have or have ever had slowed breathing or asthma; lung disease such as chronic obstructive pulmonary disease (COPD); a head injury or any condition that increases the pressure in your brain; or kyphoscoliosis (curving of the spine that may cause breathing problems).

Taking other medications with oxycodone may increase your risk of breathing problems. Tell your doctor about all medicines, including supplements, that you are taking.

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